Modesto Orozco

Orcid: 0000-0002-8608-3278

According to our database1, Modesto Orozco authored at least 72 papers between 1988 and 2023.

Collaborative distances:
  • Dijkstra number2 of four.
  • Erdős number3 of four.

Timeline

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Bibliography

2023
Sequence-Dependent Properties of the RNA Duplex.
J. Chem. Inf. Model., August, 2023

High-Throughput Prediction of the Impact of Genetic Variability on Drug Sensitivity and Resistance Patterns for Clinically Relevant Epidermal Growth Factor Receptor Mutations from Atomistic Simulations.
J. Chem. Inf. Model., 2023

2022
Molecular basis of Arginine and Lysine DNA sequence-dependent thermo-stability modulation.
PLoS Comput. Biol., 2022

BioExcel Building Blocks Workflows (BioBB-Wfs), an integrated web-based platform for biomolecular simulations.
Nucleic Acids Res., 2022

BioExcel Building Blocks REST API (BioBB REST API), programmatic access to interoperable biomolecular simulation tools.
Bioinform., 2022

2021
The Impact of the HydroxyMethylCytosine epigenetic signature on DNA structure and function.
PLoS Comput. Biol., 2021

2020
Molywood: streamlining the design and rendering of molecular movies.
Bioinform., 2020

2019
VeriNA3d: an R package for nucleic acids data mining.
Bioinform., 2019

2017
Inhibition of Human Enhancer of Zeste Homolog 2 with Tambjamine Analogs.
J. Chem. Inf. Model., August, 2017

PMut: a web-based tool for the annotation of pathological variants on proteins, 2017 update.
Nucleic Acids Res., 2017

2016
pyPcazip: A PCA-based toolkit for compression and analysis of molecular simulation data.
SoftwareX, 2016

The Differential Response of Proteins to Macromolecular Crowding.
PLoS Comput. Biol., 2016

BIGNASim: a NoSQL database structure and analysis portal for nucleic acids simulation data.
Nucleic Acids Res., 2016

Computational Prediction of HIV-1 Resistance to Protease Inhibitors.
J. Chem. Inf. Model., 2016

2015
SEABED: Small molEcule activity scanner weB servicE baseD.
Bioinform., 2015

2013
Understanding the Connection between Epigenetic DNA Methylation and Nucleosome Positioning from Computer Simulations.
PLoS Comput. Biol., 2013

Exploring Early Stages of the Chemical Unfolding of Proteins at the Proteome Scale.
PLoS Comput. Biol., 2013

NAFlex: a web server for the study of nucleic acid flexibility.
Nucleic Acids Res., 2013

Exploration of conformational transition pathways from coarse-grained simulations.
Bioinform., 2013

2012
Defining the Nature of Thermal Intermediate in 3 State Folding Proteins: Apoflavodoxin, a Study Case.
PLoS Comput. Biol., 2012

MDWeb and MDMoby: an integrated web-based platform for molecular dynamics simulations.
Bioinform., 2012

2011
Nucleotide Binding Switches the Information Flow in Ras GTPases.
PLoS Comput. Biol., 2011

Scoring by Intermolecular Pairwise Propensities of Exposed Residues (SIPPER): A New Efficient Potential for Protein-Protein Docking.
J. Chem. Inf. Model., 2011

nucleR: a package for non-parametric nucleosome positioning.
Bioinform., 2011

2010
Performance of the IEF-MST solvation continuum model in the SAMPL2 blind test prediction of hydration and tautomerization free energies.
J. Comput. Aided Mol. Des., 2010

2009
FlexServ: an integrated tool for the analysis of protein flexibility.
Bioinform., 2009

2008
DNAlive: a tool for the physical analysis of DNA at the genomic scale.
Bioinform., 2008

2007
A consensus view of protein dynamics.
Proc. Natl. Acad. Sci. USA, 2007

The (In)dependence of Alternative Splicing and Gene Duplication.
PLoS Comput. Biol., 2007

Extension of the MST continuum solvation model to the RM1 semiempirical hamiltonian.
J. Comput. Chem., 2007

A procedure for identifying homologous alternative splicing events.
BMC Bioinform., 2007

2006
Dispersion and repulsion contributions to the solvation free energy: Comparison of quantum mechanical and classical approaches in the polarizable continuum model.
J. Comput. Chem., 2006

2005
PupasView: a visual tool for selecting suitable SNPs, with putative pathological effect in genes, for genotyping purposes.
Nucleic Acids Res., 2005

Hydrophobic Molecular Similarity from MST Fractional Contributions to the Octanol/water Partition Coefficient.
J. Comput. Aided Mol. Des., 2005

PMUT: a web-based tool for the annotation of pathological mutations on proteins.
Bioinform., 2005

2004
Comparison of Active Centers of Proteins: The Kinesin Family as a Test Case.
Proceedings of the 5th Annual Spanish Bioinformatics Conference, Barcelona, Catalonia, 2004

Comparative Study of MAPK 9 Alternative Splicing from Human and Mouse.
Proceedings of the 5th Annual Spanish Bioinformatics Conference, Barcelona, Catalonia, 2004

Hydration Free Energy in Macromolecules.
Proceedings of the 5th Annual Spanish Bioinformatics Conference, Barcelona, Catalonia, 2004

Triplex-Forming Sequences in Regulatory Regions.
Proceedings of the 5th Annual Spanish Bioinformatics Conference, Barcelona, Catalonia, 2004

Annotation of Non-Human Pathological Mutations utilising Human-Parameterised Neural Networks.
Proceedings of the 5th Annual Spanish Bioinformatics Conference, Barcelona, Catalonia, 2004

2003
Continuum and discrete calculation of fractional contributions to solvation free energy.
J. Comput. Chem., 2003

Transferability of fragmental contributions to the octanol/water partition coefficient: An NDDO-based MST study.
J. Comput. Chem., 2003

Electrostatic component of solvation: Comparison of SCRF continuum models.
J. Comput. Chem., 2003

Energy decomposition in molecular complexes: Implications for the treatment of polarization in molecular simulations.
J. Comput. Chem., 2003

2002
Hydrophobic similarity between molecules: A MST-based hydrophobic similarity index.
J. Comput. Chem., 2002

Fast estimation of hydrogen-bonding donor and acceptor propensities: a GMIPp study.
J. Comput. Aided Mol. Des., 2002

Ligand-induced changes in the binding sites of proteins.
Bioinform., 2002

2001
Solvation in octanol: parametrization of the continuum MST model.
J. Comput. Chem., 2001

2000
Mixed QM/MM molecular electrostatic potentials.
J. Comput. Aided Mol. Des., 2000

1999
Parametrization of the GMIPp for the study of stacking interactions.
J. Comput. Chem., 1999

Monte Carlo-MST: New strategy for representation of solvent configurational space in solution.
J. Comput. Chem., 1999

Fractional description of free energies of solvation.
J. Comput. Aided Mol. Des., 1999

1998
Polarization effects in generalized molecular interaction potential: New Hamiltonian for reactivity studies and mixed QM/MM calculations.
J. Comput. Chem., 1998

1997
Suitability of density functional methods for calculation of electrostatic properties.
J. Comput. Chem., 1997

Role of the tautomerism of 2-azaadenine and 2-azahypoxanthine in substrate recognition by xanthine oxidase.
J. Comput. Aided Mol. Des., 1997

1996
Extension of MST/SCRF method to organic solvents: Ab initio and semiempirical parametrization for neutral solutes in CCl4.
J. Comput. Chem., 1996

Tautomerism of xanthine and alloxanthine: A model for substrate recognition by xanthine oxidase.
J. Comput. Aided Mol. Des., 1996

1995
Development of Optimized MST/SCRF Methods for Semiempirical Calculations: The MNDO and PM3 Hamilitonians.
J. Comput. Chem., 1995

1994
An Optimized AM1/MST Method for the MST-SCRF Representation of Solvated Systems.
J. Comput. Chem., 1994

Optimization of Solute Cavities and van der Waals Parameters in Ab Initio MST-SCRF Calculations of Neutral Molecules.
J. Comput. Chem., 1994

Comparison of NDDO and Quasi-Ab Initio Approaches to Compute Semiempirical Molecular Electrostatic Potentials.
J. Comput. Chem., 1994

1993
<i>Ab initio</i> study of bond stretching: Implications in force-field parametrization for molecular mechanics and dynamics.
J. Comput. Chem., 1993

Molecular interaction potential: A new tool for the theoretical study of molecular reactivity.
J. Comput. Chem., 1993

Comparison of 6-31G*-based MST/SCRF and FEP evaluations of the free energies of hydration for small neutral molecules.
J. Comput. Chem., 1993

Accuracy of free energies of hydration for organic molecules from 6-31g*-derived partial charges.
J. Comput. Chem., 1993

Suitability of the PM3-derived molecular electrostatic potentials.
J. Comput. Chem., 1993

A new scaling procedure to correct semiempirical MEP and MEP-derived properties.
J. Comput. Aided Mol. Des., 1993

1992
On the suitability of semiempirical calculations as sources of force field parameters.
J. Comput. Aided Mol. Des., 1992

1990
A practical procedure for the determination of electrostatic charges of large molecules.
J. Comput. Aided Mol. Des., 1990

1989
POEAMS: program for outliers elimination in 'anomalous' multidimensional space.
Comput. Appl. Biosci., 1989

TEFOOL/2: a program for theoretical drug design on microcomputers.
Comput. Appl. Biosci., 1989

1988
POEMS: program for outliers elimination in multidimensional space.
Comput. Appl. Biosci., 1988


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