F. Javier Luque

Orcid: 0000-0002-8049-3567

According to our database1, F. Javier Luque authored at least 53 papers between 1988 and 2024.

Collaborative distances:
  • Dijkstra number2 of five.
  • Erdős number3 of four.

Timeline

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Bibliography

2024
On the relevance of query definition in the performance of 3D ligand-based virtual screening.
J. Comput. Aided Mol. Des., December, 2024

Binding of Cholesterol to the N-Terminal Domain of the NPC1L1 Transporter: Analysis of the Epimerization-Related Binding Selectivity and Loop Mutations.
J. Chem. Inf. Model., January, 2024

2023
Screening and Biological Evaluation of Soluble Epoxide Hydrolase Inhibitors: Assessing the Role of Hydrophobicity in the Pharmacophore-Guided Search of Novel Hits.
J. Chem. Inf. Model., May, 2023

2021
Predicting the Relative Binding Affinity for Reversible Covalent Inhibitors by Free Energy Perturbation Calculations.
J. Chem. Inf. Model., 2021

Prediction of n-octanol/water partition coefficients and acidity constants (pK<sub>a</sub>) in the SAMPL7 blind challenge with the IEFPCM-MST model.
J. Comput. Aided Mol. Des., 2021

2020
Assessing the Performance of Mixed Strategies To Combine Lipophilic Molecular Similarity and Docking in Virtual Screening.
J. Chem. Inf. Model., 2020

Prediction of the n-octanol/water partition coefficients in the SAMPL6 blind challenge from MST continuum solvation calculations.
J. Comput. Aided Mol. Des., 2020

2019
Thermal Stability of Globins: Implications of Flexibility and Heme Coordination Studied by Molecular Dynamics Simulations.
J. Chem. Inf. Model., 2019

Understanding the Mechanism of Direct Activation of AMP-Kinase: Toward a Fine Allosteric Tuning of the Kinase Activity.
J. Chem. Inf. Model., 2019

2018
Development and Validation of Molecular Overlays Derived from Three-Dimensional Hydrophobic Similarity with PharmScreen.
J. Chem. Inf. Model., 2018

2016
Development and validation of hydrophobic molecular fields derived from the quantum mechanical IEF/PCM-MST solvation models in 3D-QSAR.
J. Comput. Chem., 2016

Methodology for Evaluating the Quality of Ecosystem Maps: A Case Study in the Andes.
ISPRS Int. J. Geo Inf., 2016

2015
Transferability and additivity of dihedral parameters in polarizable and nonpolarizable empirical force fields.
J. Comput. Chem., 2015

2014
TuberQ: a <i>Mycobacterium tuberculosis</i> protein druggability database.
Database J. Biol. Databases Curation, 2014

2012
Molecular simulation methods in drug discovery: a prospective outlook.
J. Comput. Aided Mol. Des., 2012

2011
MDpocket: open-source cavity detection and characterization on molecular dynamics trajectories.
Bioinform., 2011

2010
Performance of the IEF-MST solvation continuum model in the SAMPL2 blind test prediction of hydration and tautomerization free energies.
J. Comput. Aided Mol. Des., 2010

Molecular modeling of class I and II alleles of the major histocompatibility complex in <i>Salmo salar</i>.
J. Comput. Aided Mol. Des., 2010

Virtual Domotic Systems: a 3D interaction technique to control virtual building devices using residential gateways.
Proceedings of the 2nd International Conference on Image Processing Theory Tools and Applications, 2010

2009
Toward accurate relative energy predictions of the bioactive conformation of drugs.
J. Comput. Chem., 2009

2007
Extension of the MST continuum solvation model to the RM1 semiempirical hamiltonian.
J. Comput. Chem., 2007

2006
Dispersion and repulsion contributions to the solvation free energy: Comparison of quantum mechanical and classical approaches in the polarizable continuum model.
J. Comput. Chem., 2006

2005
Hydrophobic Molecular Similarity from MST Fractional Contributions to the Octanol/water Partition Coefficient.
J. Comput. Aided Mol. Des., 2005

2004
Hydration Free Energy in Macromolecules.
Proceedings of the 5th Annual Spanish Bioinformatics Conference, Barcelona, Catalonia, 2004

2003
Continuum and discrete calculation of fractional contributions to solvation free energy.
J. Comput. Chem., 2003

Transferability of fragmental contributions to the octanol/water partition coefficient: An NDDO-based MST study.
J. Comput. Chem., 2003

Electrostatic component of solvation: Comparison of SCRF continuum models.
J. Comput. Chem., 2003

Energy decomposition in molecular complexes: Implications for the treatment of polarization in molecular simulations.
J. Comput. Chem., 2003

2002
Hydrophobic similarity between molecules: A MST-based hydrophobic similarity index.
J. Comput. Chem., 2002

Fast estimation of hydrogen-bonding donor and acceptor propensities: a GMIPp study.
J. Comput. Aided Mol. Des., 2002

Ligand-induced changes in the binding sites of proteins.
Bioinform., 2002

2001
Solvation in octanol: parametrization of the continuum MST model.
J. Comput. Chem., 2001

2000
Mixed QM/MM molecular electrostatic potentials.
J. Comput. Aided Mol. Des., 2000

1999
Parametrization of the GMIPp for the study of stacking interactions.
J. Comput. Chem., 1999

Monte Carlo-MST: New strategy for representation of solvent configurational space in solution.
J. Comput. Chem., 1999

Fractional description of free energies of solvation.
J. Comput. Aided Mol. Des., 1999

1998
Polarization effects in generalized molecular interaction potential: New Hamiltonian for reactivity studies and mixed QM/MM calculations.
J. Comput. Chem., 1998

1997
Suitability of density functional methods for calculation of electrostatic properties.
J. Comput. Chem., 1997

Role of the tautomerism of 2-azaadenine and 2-azahypoxanthine in substrate recognition by xanthine oxidase.
J. Comput. Aided Mol. Des., 1997

1996
Extension of MST/SCRF method to organic solvents: Ab initio and semiempirical parametrization for neutral solutes in CCl4.
J. Comput. Chem., 1996

Tautomerism of xanthine and alloxanthine: A model for substrate recognition by xanthine oxidase.
J. Comput. Aided Mol. Des., 1996

1995
Development of Optimized MST/SCRF Methods for Semiempirical Calculations: The MNDO and PM3 Hamilitonians.
J. Comput. Chem., 1995

1994
An Optimized AM1/MST Method for the MST-SCRF Representation of Solvated Systems.
J. Comput. Chem., 1994

Optimization of Solute Cavities and van der Waals Parameters in Ab Initio MST-SCRF Calculations of Neutral Molecules.
J. Comput. Chem., 1994

Comparison of NDDO and Quasi-Ab Initio Approaches to Compute Semiempirical Molecular Electrostatic Potentials.
J. Comput. Chem., 1994

1993
<i>Ab initio</i> study of bond stretching: Implications in force-field parametrization for molecular mechanics and dynamics.
J. Comput. Chem., 1993

Molecular interaction potential: A new tool for the theoretical study of molecular reactivity.
J. Comput. Chem., 1993

Comparison of 6-31G*-based MST/SCRF and FEP evaluations of the free energies of hydration for small neutral molecules.
J. Comput. Chem., 1993

Suitability of the PM3-derived molecular electrostatic potentials.
J. Comput. Chem., 1993

A new scaling procedure to correct semiempirical MEP and MEP-derived properties.
J. Comput. Aided Mol. Des., 1993

1990
A practical procedure for the determination of electrostatic charges of large molecules.
J. Comput. Aided Mol. Des., 1990

1989
POEAMS: program for outliers elimination in 'anomalous' multidimensional space.
Comput. Appl. Biosci., 1989

1988
POEMS: program for outliers elimination in multidimensional space.
Comput. Appl. Biosci., 1988


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