Dragos Horvath

Orcid: 0000-0003-0173-5714

According to our database1, Dragos Horvath authored at least 56 papers between 1995 and 2024.

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Bibliography

2024
De Novo Drug Design - Do We Really Want to Be "Original"? - A Real-world Case Study on Colchicine-Site Tubulin Binders.
Proceedings of the Artificial Neural Networks and Machine Learning - ICANN 2024, 2024

Combinatorial Library Neural Network (CoLiNN) for Combinatorial Library Visualization Without Compound Enumeration.
Proceedings of the Artificial Neural Networks and Machine Learning - ICANN 2024, 2024

2023
Meta-GTM: Visualization and Analysis of the Chemical Library Space.
J. Chem. Inf. Model., September, 2023

GENERA: A Combined Genetic/Deep-Learning Algorithm for Multiobjective Target-Oriented De Novo Design.
J. Chem. Inf. Model., August, 2023

Chemical Library Space: Definition and DNA-Encoded Library Comparison Study Case.
J. Chem. Inf. Model., July, 2023

2022
A Close-up Look at the Chemical Space of Commercially Available Building Blocks for Medicinal Chemistry.
J. Chem. Inf. Model., 2022

SynthI: A New Open-Source Tool for Synthon-Based Library Design.
J. Chem. Inf. Model., 2022

Chemspace Atlas: Multiscale Chemography of Ultralarge Libraries for Drug Discovery.
J. Chem. Inf. Model., 2022

Inverse QSAR: Reversing Descriptor-Driven Prediction Pipeline Using Attention-Based Conditional Variational Autoencoder.
J. Chem. Inf. Model., 2022

HIV-1 drug resistance profiling using amino acid sequence space cartography.
Bioinform., 2022

2021
Chemography: Searching for Hidden Treasures.
J. Chem. Inf. Model., 2021

2020
Trustworthiness, the Key to Grid-Based Map-Driven Predictive Model Enhancement and Applicability Domain Control.
J. Chem. Inf. Model., 2020

"Big Data" Fast Chemoinformatics Model to Predict Generalized Born Radius and Solvent Accessibility as a Function of Geometry.
J. Chem. Inf. Model., 2020

Diversifying chemical libraries with generative topographic mapping.
J. Comput. Aided Mol. Des., 2020

2019
De Novo Molecular Design by Combining Deep Autoencoder Recurrent Neural Networks with Generative Topographic Mapping.
J. Chem. Inf. Model., 2019

CovaDOTS: In Silico Chemistry-Driven Tool to Design Covalent Inhibitors Using a Linking Strategy.
J. Chem. Inf. Model., 2019

Virtual Screening with Generative Topographic Maps: How Many Maps Are Required?
J. Chem. Inf. Model., 2019

Multi-task generative topographic mapping in virtual screening.
J. Comput. Aided Mol. Des., 2019

2018
Rescoring of docking poses under Occam's Razor: are there simpler solutions?
J. Comput. Aided Mol. Des., 2018

2017
Privileged Structural Motif Detection and Analysis Using Generative Topographic Maps.
J. Chem. Inf. Model., 2017

QSAR modeling and chemical space analysis of antimalarial compounds.
J. Comput. Aided Mol. Des., 2017

From bird's eye views to molecular communities: two-layered visualization of structure-activity relationships in large compound data sets.
J. Comput. Aided Mol. Des., 2017

2016
Kernel Target Alignment Parameter: A New Modelability Measure for Regression Tasks.
J. Chem. Inf. Model., 2016

Chemical Space Mapping and Structure-Activity Analysis of the ChEMBL Antiviral Compound Set.
J. Chem. Inf. Model., 2016

Prediction of Activity Cliffs Using Condensed Graphs of Reaction Representations, Descriptor Recombination, Support Vector Machine Classification, and Support Vector Regression.
J. Chem. Inf. Model., 2016

2015
Expert System for Predicting Reaction Conditions: The Michael Reaction Case.
J. Chem. Inf. Model., 2015

Stargate GTM: Bridging Descriptor and Activity Spaces.
J. Chem. Inf. Model., 2015

Chemical Data Visualization and Analysis with Incremental Generative Topographic Mapping: Big Data Challenge.
J. Chem. Inf. Model., 2015

Mappability of drug-like space: towards a polypharmacologically competent map of drug-relevant compounds.
J. Comput. Aided Mol. Des., 2015

2014
Computational chemogenomics: Is it more than inductive transfer?
J. Comput. Aided Mol. Des., 2014

2013
Do Not Hesitate to Use Tversky - and Other Hints for Successful Active Analogue Searches with Feature Count Descriptors.
J. Chem. Inf. Model., 2013

In Silico Fragment-Based Drug Discovery: Setup and Validation of a Fragment-to-Lead Computational Protocol Using S4MPLE.
J. Chem. Inf. Model., 2013

S4MPLE - Sampler For Multiple Protein-Ligand Entities: Simultaneous Docking of Several Entities.
J. Chem. Inf. Model., 2013

Generative Topographic Mapping-Based Classification Models and Their Applicability Domain: Application to the Biopharmaceutics Drug Disposition Classification System (BDDCS).
J. Chem. Inf. Model., 2013

2012
Models for Identification of Erroneous Atom-to-Atom Mapping of Reactions Performed by Automated Algorithms.
J. Chem. Inf. Model., 2012

Mining Chemical Reactions Using Neighborhood Behavior and Condensed Graphs of Reactions Approaches.
J. Chem. Inf. Model., 2012

2011
Local neighborhood behavior in a combinatorial library context.
J. Comput. Aided Mol. Des., 2011

Hill-Climbing search and diversification within an evolutionary approach to protein structure prediction.
BioData Min., 2011

2010
Single- and Multi-Objective Cooperation for the Flexible Docking Problem.
J. Math. Model. Algorithms, 2010

Applicability Domains for Classification Problems: Benchmarking of Distance to Models for Ames Mutagenicity Set.
J. Chem. Inf. Model., 2010

A unified approach to the applicability domain problem of QSAR models.
J. Cheminformatics, 2010

An Evolutionary Model Based on Hill-Climbing Search Operators for Protein Structure Prediction.
Proceedings of the Evolutionary Computation, 2010

Simplified chain folding models as metaheuristic benchmark for tuning real protein folding algorithms?
Proceedings of the IEEE Congress on Evolutionary Computation, 2010

2009
Predicting the Predictability: A Unified Approach to the Applicability Domain Problem of QSAR Models.
J. Chem. Inf. Model., 2009

Local vs. global search strategies in evolutionary GRID-based conformational sampling & docking.
Proceedings of the IEEE Congress on Evolutionary Computation, 2009

2008
Fuzzy Tricentric Pharmacophore Fingerprints. 2. Application of Topological Fuzzy Pharmacophore Triplets in Quantitative Structure-Activity Relationships.
J. Chem. Inf. Model., 2008

Parallel multi-objective algorithms for the molecular docking problem.
Proceedings of the 2008 IEEE Symposium on Computational Intelligence in Bioinformatics and Computational Biology, 2008

2007
Optimized Evolutionary Strategies in Conformational Sampling.
Soft Comput., 2007

Stochastic versus Stepwise Strategies for Quantitative Structure-Activity Relationship GenerationHow Much Effort May the Mining for Successful QSAR Models Take?
J. Chem. Inf. Model., 2007

A parallel hybrid genetic algorithm for protein structure prediction on the computational grid.
Future Gener. Comput. Syst., 2007

Grid-based evolutionary strategies applied to the conformational sampling problem.
Proceedings of the IEEE Congress on Evolutionary Computation, 2007

2006
Fuzzy Tricentric Pharmacophore Fingerprints, 1. Topological Fuzzy Pharmacophore Triplets and Adapted Molecular Similarity Scoring Schemes.
J. Chem. Inf. Model., 2006

2003
Neighborhood Behavior of in Silico Structural Spaces with Respect to In Vitro Activity Spaces-A Benchmark for Neighborhood Behavior Assessment of Different in Silico Similarity Metrics.
J. Chem. Inf. Comput. Sci., 2003

Neighborhood Behavior of in Silico Structural Spaces with Respect to in Vitro Activity Spaces-A Novel Understanding of the Molecular Similarity Principle in the Context of Multiple Receptor Binding Profiles.
J. Chem. Inf. Comput. Sci., 2003

1999
Reactivity Prediction Models Applied to the Selection of Novel Candidate Building Blocks for High-Throughput Organic Synthesis of Combinatorial Libraries.
J. Chem. Inf. Comput. Sci., 1999

1995
Molecular Topology, 15. 3D Distance Matrixes and Related Topological Indices.
J. Chem. Inf. Comput. Sci., 1995


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