Benjamin J. Raphael

Orcid: 0000-0003-1274-048X

Affiliations:
  • Princeton University, Princeton, NJ, USA
  • Brown University, Providence, RI, USA (former)


According to our database1, Benjamin J. Raphael authored at least 84 papers between 2003 and 2024.

Collaborative distances:

Awards

ACM Fellow

ACM Fellow 2023, "For contributions to computational biology including algorithms in cancer genomics/evolution and biological network analysis ".

Timeline

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Bibliography

2024
Maximum Likelihood Inference of Time-Scaled Cell Lineage Trees with Mixed-Type Missing Data.
Proceedings of the Research in Computational Molecular Biology, 2024

Inferring Allele-Specific Copy Number Aberrations and Tumor Phylogeography from Spatially Resolved Transcriptomics.
Proceedings of the Research in Computational Molecular Biology, 2024

DeST-OT: Alignment of Spatiotemporal Transcriptomics Data.
Proceedings of the Research in Computational Molecular Biology, 2024

Mapping the Topography of Spatial Gene Expression with Interpretable Deep Learning.
Proceedings of the Research in Computational Molecular Biology, 2024

2023
A zero-agnostic model for copy number evolution in cancer.
PLoS Comput. Biol., November, 2023

2022
NetMix2: A Principled Network Propagation Algorithm for Identifying Altered Subnetworks.
J. Comput. Biol., 2022

A Maximum Parsimony Principle for Multichromosomal Complex Genome Rearrangements.
Proceedings of the 22nd International Workshop on Algorithms in Bioinformatics, 2022

Belayer: Modeling Discrete and Continuous Spatial Variation in Gene Expression from Spatially Resolved Transcriptomics.
Proceedings of the Research in Computational Molecular Biology, 2022

NetMix2: Unifying Network Propagation and Altered Subnetworks.
Proceedings of the Research in Computational Molecular Biology, 2022

2021
NetMix: A Network-Structured Mixture Model for Reduced-Bias Estimation of Altered Subnetworks.
J. Comput. Biol., May, 2021

Genome Halving and Aliquoting Under the Copy Number Distance.
Proceedings of the 21st International Workshop on Algorithms in Bioinformatics, 2021

Quantifying and Reducing Bias in Maximum Likelihood Estimation of Structured Anomalies.
Proceedings of the 38th International Conference on Machine Learning, 2021

2020
Analyses of non-coding somatic drivers in 2,658 cancer whole genomes.
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Nat., 2020

The evolutionary history of 2,658 cancers.
Nat., 2020

Quantifying and Reducing Bias in Maximum Likelihood Estimation of Structured Anomalies.
CoRR, 2020

Copy number evolution with weighted aberrations in cancer.
Bioinform., 2020

Identifying tumor clones in sparse single-cell mutation data.
Bioinform., 2020

Single-Cell Tumor Phylogeny Inference with Copy-Number Constrained Mutation Losses.
Proceedings of the Research in Computational Molecular Biology, 2020

2019
12 Grand Challenges in Single-Cell Data Science.
PeerJ Prepr., 2019

Inferring Tumor Evolution from Longitudinal Samples.
Proceedings of the Research in Computational Molecular Biology, 2019

netNMF-sc: A Network Regularization Algorithm for Dimensionality Reduction and Imputation of Single-Cell Expression Data.
Proceedings of the Research in Computational Molecular Biology, 2019

Random Walks on Hypergraphs with Edge-Dependent Vertex Weights.
Proceedings of the 36th International Conference on Machine Learning, 2019

2018
Phylogenetic Copy-Number Factorization of Multiple Tumor Samples.
J. Comput. Biol., 2018

Using controls to limit false discovery in the era of big data.
BMC Bioinform., 2018

Haplotype phasing in single-cell DNA-sequencing data.
Bioinform., 2018

Hierarchical HotNet: identifying hierarchies of altered subnetworks.
Bioinform., 2018

Identifying simultaneous rearrangements in cancer genomes.
Bioinform., 2018

Identifying structural variants using linked-read sequencing data.
Bioinform., 2018

2017
Tumor phylogeny inference using tree-constrained importance sampling.
Bioinform., 2017

Complexity and algorithms for copy-number evolution problems.
Algorithms Mol. Biol., 2017

The Copy-Number Tree Mixture Deconvolution Problem and Applications to Multi-sample Bulk Sequencing Tumor Data.
Proceedings of the Research in Computational Molecular Biology, 2017

2016
On the Sample Complexity of Cancer Pathways Identification.
J. Comput. Biol., 2016

Identification of hierarchical chromatin domains.
Bioinform., 2016

A weighted exact test for mutually exclusive mutations in cancer.
Bioinform., 2016

Copy-Number Evolution Problems: Complexity and Algorithms.
Proceedings of the Algorithms in Bioinformatics - 16th International Workshop, 2016

Multi-state Perfect Phylogeny Mixture Deconvolution and Applications to Cancer Sequencing.
Proceedings of the Research in Computational Molecular Biology - 20th Annual Conference, 2016

2015
Accurate Computation of Survival Statistics in Genome-Wide Studies.
PLoS Comput. Biol., 2015

Simultaneous Inference of Cancer Pathways and Tumor Progression from Cross-Sectional Mutation Data.
J. Comput. Biol., 2015

Reconstruction of clonal trees and tumor composition from multi-sample sequencing data.
Bioinform., 2015

CoMEt: A Statistical Approach to Identify Combinations of Mutually Exclusive Alterations in Cancer.
Proceedings of the Research in Computational Molecular Biology, 2015

Session Introduction.
Proceedings of the Biocomputing 2015: Proceedings of the Pacific Symposium, 2015

2014
Detecting independent and recurrent copy number aberrations using interval graphs.
Bioinform., 2014

Characterization of structural variants with single molecule and hybrid sequencing approaches.
Bioinform., 2014

Quantifying tumor heterogeneity in whole-genome and whole-exome sequencing data.
Bioinform., 2014

A combinatorial approach for analyzing intra-tumor heterogeneity from high-throughput sequencing data.
Bioinform., 2014

Reconstructing Mutational History in Multiply Sampled Tumors Using Perfect Phylogeny Mixtures.
Proceedings of the Algorithms in Bioinformatics - 14th International Workshop, 2014

A combinatorial algorithm to identify independent and recurrent copy number aberrations across cancer types.
Proceedings of the IEEE 4th International Conference on Computational Advances in Bio and Medical Sciences, 2014

2013
Simultaneous Identification of Multiple Driver Pathways in Cancer.
PLoS Comput. Biol., 2013

Genome-Wide Survival Analysis of Somatic Mutations in Cancer.
Proceedings of the Research in Computational Molecular Biology, 2013

Inferring Intra-tumor Heterogeneity from High-Throughput DNA Sequencing Data.
Proceedings of the Research in Computational Molecular Biology, 2013

Session introduction.
Proceedings of the Biocomputing 2013: Proceedings of the Pacific Symposium, 2013

Modeling cell heterogeneity: from single-cell variations to mixed cells populations.
Proceedings of the Biocomputing 2013: Proceedings of the Pacific Symposium, 2013

Identifying significant mutations in large cohorts of cancer genomes.
Proceedings of the IEEE 3rd International Conference on Computational Advances in Bio and Medical Sciences, 2013

Workshop: Reconstructing the organization of cancer genomes.
Proceedings of the IEEE 3rd International Conference on Computational Advances in Bio and Medical Sciences, 2013

2012
Chapter 6: Structural Variation and Medical Genomics.
PLoS Comput. Biol., 2012

Algorithms and Genome Sequencing: Identifying Driver Pathways in Cancer.
Computer, 2012

Reconstructing cancer genomes from paired-end sequencing data.
BMC Bioinform., 2012

Reconstructing genome mixtures from partial adjacencies.
BMC Bioinform., 2012

Identification of polymorphic inversions from genotypes.
BMC Bioinform., 2012

Finding Driver Pathways in Cancer: Models and Algorithms.
Algorithms Mol. Biol., 2012

Discovery of Mutated Subnetworks Associated with Clinical Data in Cancer.
Proceedings of the Biocomputing 2012: Proceedings of the Pacific Symposium, 2012

Workshop: Algorithms for discovery of mutated pathways in cancer.
Proceedings of the IEEE 2nd International Conference on Computational Advances in Bio and Medical Sciences, 2012

2011
Algorithms for Detecting Significantly Mutated Pathways in Cancer.
J. Comput. Biol., 2011

Detection of recurrent rearrangement breakpoints from copy number data.
BMC Bioinform., 2011

<i>De Novo</i> Discovery of Mutated Driver Pathways in Cancer.
Proceedings of the Research in Computational Molecular Biology, 2011

Workshop: Characterization of structural variants with next generation DNA sequencing.
Proceedings of the IEEE 1st International Conference on Computational Advances in Bio and Medical Sciences, 2011

2010
Gremlin: An Interactive Visualization Model for Analyzing Genomic Rearrangements.
IEEE Trans. Vis. Comput. Graph., 2010

Identification and Frequency Estimation of Inversion Polymorphisms from Haplotype Data.
J. Comput. Biol., 2010

Optimizing PCR Assays for DNA-Based Cancer Diagnostics.
J. Comput. Biol., 2010

Structural variation analysis with strobe reads.
Bioinform., 2010

Parsimony and likelihood reconstruction of human segmental duplications.
Bioinform., 2010

Efficient algorithms for analyzing segmental duplications with deletions and inversions in genomes.
Algorithms Mol. Biol., 2010

2009
A geometric approach for classification and comparison of structural variants.
Bioinform., 2009

Discovery of phosphorylation motif mixtures in phosphoproteomics data.
Bioinform., 2009

A Parsimony Approach to Analysis of Human Segmental Duplications.
Proceedings of the Biocomputing 2009: Proceedings of the Pacific Symposium, 2009

2008
Evaluation of Paired-End Sequencing Strategies for Detection of Genome Rearrangements in Cancer.
PLoS Comput. Biol., 2008

Analysis of segmental duplications via duplication distance.
Proceedings of the ECCB'08 Proceedings, 2008

2007
Optimization of primer design for the detection of variable genomic lesions in cancer.
Bioinform., 2007

Identification of Deletion Polymorphisms from Haplotypes.
Proceedings of the Research in Computational Molecular Biology, 2007

2006
Microinversions in mammalian evolution.
Proc. Natl. Acad. Sci. USA, 2006

AliWABA: alignment on the web through an A-Bruijn approach.
Nucleic Acids Res., 2006

2004
A Uniform Projection Method for Motif Discovery in DNA Sequences.
IEEE ACM Trans. Comput. Biol. Bioinform., 2004

Reconstructing tumor amplisomes.
Proceedings of the Proceedings Twelfth International Conference on Intelligent Systems for Molecular Biology/Third European Conference on Computational Biology 2004, 2004

2003
Reconstructing tumor genome architectures.
Proceedings of the European Conference on Computational Biology (ECCB 2003), 2003


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