2025
SPIRiT-Diffusion: Self-Consistency Driven Diffusion Model for Accelerated MRI.
IEEE Trans. Medical Imaging, February, 2025
Generalizable Reconstruction for Accelerating MR Imaging via Federated Learning With Neural Architecture Search.
IEEE Trans. Medical Imaging, January, 2025
2024
IG-GCN: Empowering e-Health Services for Alzheimer's Disease Prediction.
IEEE Trans. Consumer Electron., November, 2024
MMCA-NET: A Multimodal Cross Attention Transformer Network for Nasopharyngeal Carcinoma Tumor Segmentation Based on a Total-Body PET/CT System.
,
,
,
,
,
,
,
,
,
,
,
IEEE J. Biomed. Health Informatics, September, 2024
Accurate Whole-Brain Image Enhancement for Low-Dose Integrated PET/MR Imaging Through Spatial Brain Transformation.
IEEE J. Biomed. Health Informatics, September, 2024
Non-Invasive Quantification of the Brain [¹⁸F]FDG-PET Using Inferred Blood Input Function Learned From Total-Body Data With Physical Constraint.
,
,
,
,
,
,
,
,
,
,
,
,
IEEE Trans. Medical Imaging, July, 2024
Noise-Generating and Imaging Mechanism Inspired Implicit Regularization Learning Network for Low Dose CT Reconstrution.
IEEE Trans. Medical Imaging, May, 2024
High-Frequency Space Diffusion Model for Accelerated MRI.
IEEE Trans. Medical Imaging, May, 2024
A New Method of Plane-Wave Ultrasound Imaging Based on Reverse Time Migration.
,
,
,
,
,
,
,
,
,
,
IEEE Trans. Biomed. Eng., May, 2024
OIF-Net: An Optical Flow Registration-Based PET/MR Cross-Modal Interactive Fusion Network for Low-Count Brain PET Image Denoising.
,
,
,
,
,
,
,
,
,
,
,
,
IEEE Trans. Medical Imaging, April, 2024
A Multiplexed 32 × 32 2D Matrix Array Transducer for Flexible Sub-Aperture Volumetric Ultrasound Imaging.
,
,
,
,
,
,
,
,
,
,
IEEE Trans. Biomed. Eng., March, 2024
Super Resolution Dual-Energy Cone-Beam CT Imaging With Dual-Layer Flat-Panel Detector.
,
,
,
,
,
,
,
,
,
,
IEEE Trans. Medical Imaging, February, 2024
Deep Generalized Learning Model for PET Image Reconstruction.
,
,
,
,
,
,
,
,
,
,
,
,
,
IEEE Trans. Medical Imaging, January, 2024
ISP-IRLNet: Joint optimization of interpretable sampler and implicit regularization learning network for accerlerated MRI.
Pattern Recognit., 2024
Enhancing the vision-language foundation model with key semantic knowledge-emphasized report refinement.
Medical Image Anal., 2024
An improved medical image segmentation framework with Channel-Height-Width-Spatial attention module.
Eng. Appl. Artif. Intell., 2024
Diff5T: Benchmarking Human Brain Diffusion MRI with an Extensive 5.0 Tesla K-Space and Spatial Dataset.
,
,
,
,
,
,
,
,
,
,
,
,
,
,
,
,
CoRR, 2024
Guided MRI Reconstruction via Schrödinger Bridge.
CoRR, 2024
SamRobNODDI: Q-Space Sampling-Augmented Continuous Representation Learning for Robust and Generalized NODDI.
CoRR, 2024
DeepMpMRI: Tensor-decomposition Regularized Learning for Fast and High-Fidelity Multi-Parametric Microstructural MR Imaging.
,
,
,
,
,
,
,
,
,
,
CoRR, 2024
Pathology-genomic fusion via biologically informed cross-modality graph learning for survival analysis.
CoRR, 2024
Swin-UMamba: Mamba-based UNet with ImageNet-based pretraining.
,
,
,
,
,
,
,
,
,
,
CoRR, 2024
Accurate Delineation of Cerebrovascular Structures from TOF-MRA with Connectivity-Reinforced Deep Learning.
Proceedings of the Machine Learning in Medical Imaging - 15th International Workshop, 2024
Swin-UMamba: Mamba-Based UNet with ImageNet-Based Pretraining.
,
,
,
,
,
,
,
,
,
,
,
Proceedings of the Medical Image Computing and Computer Assisted Intervention - MICCAI 2024, 2024
Blind Proximal Diffusion Model for Joint Image and Sensitivity Estimation in Parallel MRI.
Proceedings of the Medical Image Computing and Computer Assisted Intervention - MICCAI 2024, 2024
Quantum Neural Network for Accelerated Magnetic Resonance Imaging.
Proceedings of the IEEE International Conference on Imaging Systems and Techniques, 2024
Multimodal Self-Supervised Learning for Lesion Localization.
Proceedings of the IEEE International Symposium on Biomedical Imaging, 2024
Simultaneous Q-Space Sampling Optimization and Reconstruction for Fast and High-Fidelity Diffusion Magnetic Resonance Imaging.
Proceedings of the IEEE International Symposium on Biomedical Imaging, 2024
MAKEN: Improving Medical Report Generation with Adapter Tuning and Knowledge Enhancement in Vision-Language Foundation Models.
Proceedings of the IEEE International Symposium on Biomedical Imaging, 2024
Mlip: Medical Language-Image Pre-Training With Masked Local Representation Learning.
Proceedings of the IEEE International Symposium on Biomedical Imaging, 2024
Pediatric TSC-Related Epilepsy Classification from Clinical Mr Images Using Quantum Neural Network.
,
,
,
,
,
,
,
,
,
,
Proceedings of the IEEE International Symposium on Biomedical Imaging, 2024
Enhancing Representation in Medical Vision-Language Foundation Models Via Multi-Scale Information Extraction Techniques.
Proceedings of the IEEE International Symposium on Biomedical Imaging, 2024
C2RG: Parameter-efficient Adaptation of 3D Vision and Language Foundation Model for Coronary CTA Report Generation.
Proceedings of the IEEE International Conference on Bioinformatics and Biomedicine, 2024
2023
Flexible Ultrasound Transducer With Embedded Optical Shape Sensing Fiber for Biomedical Imaging Applications.
,
,
,
,
,
,
,
,
,
,
IEEE Trans. Biomed. Eng., October, 2023
A Two-Branch Neural Network for Short-Axis PET Image Quality Enhancement.
,
,
,
,
,
,
,
,
,
,
,
IEEE J. Biomed. Health Informatics, June, 2023
A Novel Dual-Element Catheter for Improving Non-Uniform Rotational Distortion in Intravascular Ultrasound.
IEEE Trans. Biomed. Eng., June, 2023
PARCEL: Physics-Based Unsupervised Contrastive Representation Learning for Multi-Coil MR Imaging.
IEEE ACM Trans. Comput. Biol. Bioinform., 2023
Adaptive weighted curvature-based active contour for ultrasonic and 3T/5T MR image segmentation.
,
,
,
,
,
,
,
,
,
,
,
Signal Process., 2023
A review of security issues and solutions for precision health in Internet-of-Medical-Things systems.
Secur. Saf., 2023
Improving Medical Report Generation with Adapter Tuning and Knowledge Enhancement in Vision-Language Foundation Models.
CoRR, 2023
SPIRiT-Diffusion: Self-Consistency Driven Diffusion Model for Accelerated MRI.
CoRR, 2023
CardiacSeg: Customized Pre-training Volumetric Transformer with Scaling Pyramid for 3D Cardiac Segmentation.
Proceedings of the Statistical Atlases and Computational Models of the Heart. Regular and CMRxRecon Challenge Papers, 2023
Partial-Labeled Abdominal Organ and Cancer Segmentation via Cascaded Dual-Decoding U-Net.
Proceedings of the Fast, Low-resource, and Accurate Organ and Pan-cancer Segmentation in Abdomen CT, 2023
Semi-Supervised and Self-Supervised Collaborative Learning for Prostate 3D MR Image Segmentation.
Proceedings of the 20th IEEE International Symposium on Biomedical Imaging, 2023
Uncertainty-Aware Multi-Parametric Magnetic Resonance Image Information Fusion for 3D Object Segmentation.
Proceedings of the 20th IEEE International Symposium on Biomedical Imaging, 2023
2022
Transformable Ultrasonic Array Transducer for Multiscale Imaging and Beamforming.
,
,
,
,
,
,
,
,
,
,
IEEE Trans. Ind. Electron., 2022
3D Acoustic Manipulation of Living Cells and Organisms Based On 2D Array.
IEEE Trans. Biomed. Eng., 2022
Endoscopic Ultrasound Localization Microscopy for the Evaluation of the Microvasculature of Gastrointestinal Tract Tumors in Rabbits.
,
,
,
,
,
,
,
,
,
,
IEEE Trans. Biomed. Eng., 2022
High Temporal Resolution Total-Body Dynamic PET Imaging Based on Pixel-Level Time-Activity Curve Correction.
IEEE Trans. Biomed. Eng., 2022
Dedicated Photoacoustic Imaging Instrument for Human Periphery Blood Vessels: A New Paradigm for Understanding the Vascular Health.
,
,
,
,
,
,
,
,
,
,
,
,
,
IEEE Trans. Biomed. Eng., 2022
SPIRiT-Diffusion: SPIRiT-driven Score-Based Generative Modeling for Vessel Wall imaging.
CoRR, 2022
Iterative Data Refinement for Self-Supervised MR Image Reconstruction.
CoRR, 2022
Semi-Supervised and Self-Supervised Collaborative Learning for Prostate 3D MR Image Segmentation.
CoRR, 2022
SelfCoLearn: Self-supervised collaborative learning for accelerating dynamic MR imaging.
CoRR, 2022
First Glance Diagnosis: Brain Disease Classification with Single fMRI Volume
CoRR, 2022
Rethinking the optimization process for self-supervised model-driven MRI reconstruction.
CoRR, 2022
PARCEL: Physics-based unsupervised contrastive representation learning for parallel MR imaging.
CoRR, 2022
Expert Knowledge-guided Geometric Representation Learning for Magnetic Resonance Imaging-based Glioma Grading.
CoRR, 2022
2021
Accelerated 3D bSSFP Using a Modified Wave-CAIPI Technique With Truncated Wave Gradients.
,
,
,
,
,
,
,
,
,
,
IEEE Trans. Medical Imaging, 2021
Learned Low-Rank Priors in Dynamic MR Imaging.
,
,
,
,
,
,
,
,
,
,
IEEE Trans. Medical Imaging, 2021
A Coarse-to-Fine Deformable Transformation Framework for Unsupervised Multi-Contrast MR Image Registration with Dual Consistency Constraint.
IEEE Trans. Medical Imaging, 2021
Learning a Deep CNN Denoising Approach Using Anatomical Prior Information Implemented With Attention Mechanism for Low-Dose CT Imaging on Clinical Patient Data From Multiple Anatomical Sites.
IEEE J. Biomed. Health Informatics, 2021
Multi-View Mammographic Density Classification by Dilated and Attention-Guided Residual Learning.
IEEE ACM Trans. Comput. Biol. Bioinform., 2021
MRI Based Radiomics Approach With Deep Learning for Prediction of Vessel Invasion in Early-Stage Cervical Cancer.
IEEE ACM Trans. Comput. Biol. Bioinform., 2021
Corrections to "Wearable Ultrasound Improves Motor Function in an MPTP Mouse Model of Parkinson's Disease".
IEEE Trans. Biomed. Eng., 2021
Transcranial Ultrasound Stimulation Suppresses Neuroinflammation in a Chronic Mouse Model of Parkinson's Disease.
IEEE Trans. Biomed. Eng., 2021
1.5-Dimensional Circular Array Transducer for In Vivo Endoscopic Ultrasonography.
,
,
,
,
,
,
,
,
,
,
,
,
IEEE Trans. Biomed. Eng., 2021
A Dual-Mode 2D Matrix Array for Ultrasound Image-Guided Noninvasive Therapy.
IEEE Trans. Biomed. Eng., 2021
Simultaneous Head and Spine MR Imaging in Children Using a Dedicated Multichannel Receiver System at 3T.
,
,
,
,
,
,
,
,
,
,
,
,
,
,
IEEE Trans. Biomed. Eng., 2021
Enhancing the X-Ray Differential Phase Contrast Image Quality With Deep Learning Technique.
,
,
,
,
,
,
,
,
,
,
IEEE Trans. Biomed. Eng., 2021
Ultrasound image reconstruction from plane wave radio-frequency data by self-supervised deep neural network.
Medical Image Anal., 2021
Considering anatomical prior information for low-dose CT image enhancement using attribute-augmented Wasserstein generative adversarial networks.
,
,
,
,
,
,
,
,
,
,
,
Neurocomputing, 2021
Radiomic biomarker extracted from PI-RADS 3 patients support more eìcient and robust prostate cancer diagnosis: a multi-center study.
CoRR, 2021
Deep Manifold Learning for Dynamic MR Imaging.
,
,
,
,
,
,
,
,
,
,
CoRR, 2021
Deep learning for fast MR imaging: A review for learning reconstruction from incomplete k-space data.
Biomed. Signal Process. Control., 2021
FaNet: fast assessment network for the novel coronavirus (COVID-19) pneumonia based on 3D CT imaging and clinical symptoms.
,
,
,
,
,
,
,
,
,
,
Appl. Intell., 2021
Self-supervised Learning for MRI Reconstruction with a Parallel Network Training Framework.
Proceedings of the Medical Image Computing and Computer Assisted Intervention - MICCAI 2021 - 24th International Conference, Strasbourg, France, September 27, 2021
MHD signal derived Auto Variable Velocity Encoding for 2D Flow Imaging in 3T Cardiac Magnetic Resonance Imaging.
Proceedings of the 43rd Annual International Conference of the IEEE Engineering in Medicine & Biology Society, 2021
2020
Ultrafast Endoscopic Ultrasonography With Circular Array.
IEEE Trans. Medical Imaging, 2020
A Magnetic Resonance-Guided Focused Ultrasound Neuromodulation System With a Whole Brain Coil Array for Nonhuman Primates at 3 T.
IEEE Trans. Medical Imaging, 2020
CaGAN: A Cycle-Consistent Generative Adversarial Network With Attention for Low-Dose CT Imaging.
,
,
,
,
,
,
,
,
,
,
IEEE Trans. Computational Imaging, 2020
Quantitative Estimation of Passive Elastic Properties of Individual Skeletal Muscle in Vivo Using Normalized Elastic Modulus-Length Curve.
IEEE Trans. Biomed. Eng., 2020
Non-Contact High-Frequency Ultrasound Microbeam Stimulation: A Novel Finding and Potential Causes of Cell Responses.
IEEE Trans. Biomed. Eng., 2020
Development of Multi-Layer Lateral-Mode Ultrasound Needle Transducer for Brain Stimulation in Mice.
,
,
,
,
,
,
,
,
,
,
IEEE Trans. Biomed. Eng., 2020
One-Stop MR Neurovascular Vessel Wall Imaging With a 48-Channel Coil System at 3 T.
,
,
,
,
,
,
,
,
,
,
,
,
,
IEEE Trans. Biomed. Eng., 2020
PET Image Reconstruction Using a Cascading Back-Projection Neural Network.
IEEE J. Sel. Top. Signal Process., 2020
AIDE: Annotation-efficient deep learning for automatic medical image segmentation.
,
,
,
,
,
,
,
,
,
,
,
,
,
CoRR, 2020
Multi-task MR Imaging with Iterative Teacher Forcing and Re-weighted Deep Learning.
CoRR, 2020
A coarse-to-fine framework for unsupervised multi-contrast MR image deformable registration with dual consistency constraint.
CoRR, 2020
Deep Low-rank Prior in Dynamic MR Imaging.
CoRR, 2020
Lymph-vascular space invasion prediction in cervical cancer: Exploring radiomics and deep learning multilevel features of tumor and peritumor tissue on multiparametric MRI.
Biomed. Signal Process. Control., 2020
Laplacian pyramid-based complex neural network learning for fast MR imaging.
Proceedings of the International Conference on Medical Imaging with Deep Learning, 2020
Multi-Contrast Mr Reconstruction with Enhanced Denoising Autoencoder Prior Learning.
Proceedings of the 17th IEEE International Symposium on Biomedical Imaging, 2020
Deeply-Supervised Multi-Dose Prior Learning For Low-Dose Pet Imaging.
Proceedings of the 2020 IEEE 17th International Symposium on Biomedical Imaging Workshops (ISBI Workshops), 2020
Low-Dose Pet Image Restoration With 2D And 3D Network Prior Learning.
Proceedings of the 2020 IEEE 17th International Symposium on Biomedical Imaging Workshops (ISBI Workshops), 2020
A Deep Residual Sparse and Cross Domain Reconstruction Network for Dynamic MR Imaging.
Proceedings of the ICCPR 2020: 9th International Conference on Computing and Pattern Recognition, Xiamen, China, October 30, 2020
2019
A Dual-Mode Imaging Catheter for Intravascular Ultrasound Application.
IEEE Trans. Medical Imaging, 2019
Wearable Ultrasound Improves Motor Function in an MPTP Mouse Model of Parkinson's Disease.
IEEE Trans. Biomed. Eng., 2019
Noninvasive Ultrasonic Neuromodulation in Freely Moving Mice.
,
,
,
,
,
,
,
,
,
,
,
IEEE Trans. Biomed. Eng., 2019
A Novel Racing Array Transducer for Noninvasive Ultrasonic Retinal Stimulation: A Simulation Study.
Sensors, 2019
Low-Dose Computed Tomography Image Super-Resolution Reconstruction via Random Forests.
Sensors, 2019
An Unsupervised Deep Learning Method for Parallel Cardiac MRI via Time-Interleaved Sampling.
CoRR, 2019
LANTERN: learn analysis transform network for dynamic magnetic resonance imaging with small dataset.
CoRR, 2019
Model-based Deep MR Imaging: the roadmap of generalizing compressed sensing model using deep learning.
CoRR, 2019
DeepcomplexMRI: Exploiting deep residual network for fast parallel MR imaging with complex convolution.
CoRR, 2019
CRDN: Cascaded Residual Dense Networks for Dynamic MR Imaging with Edge-enhanced Loss Constraint.
CoRR, 2019
CLCI-Net: Cross-Level Fusion and Context Inference Networks for Lesion Segmentation of Chronic Stroke.
Proceedings of the Medical Image Computing and Computer Assisted Intervention - MICCAI 2019, 2019
Learning Cross-Modal Deep Representations for Multi-Modal MR Image Segmentation.
Proceedings of the Medical Image Computing and Computer Assisted Intervention - MICCAI 2019, 2019
T1rho Fractional-order Relaxation of Human Articular Cartilage.
,
,
,
,
,
,
,
,
,
,
Proceedings of the 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2019
Susceptibility-based MR Imaging of Nitinol Stent.
Proceedings of the 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2019
2018
Learning Joint-Sparse Codes for Calibration-Free Parallel MR Imaging.
IEEE Trans. Medical Imaging, 2018
A Dedicated 36-Channel Receive Array for Fetal MRI at 3T.
,
,
,
,
,
,
,
,
,
,
,
IEEE Trans. Medical Imaging, 2018
A Radiomics Approach With CNN for Shear-Wave Elastography Breast Tumor Classification.
IEEE Trans. Biomed. Eng., 2018
A Delayed-Excitation Data Acquisition Method for High-Frequency Ultrasound Imaging.
,
,
,
,
,
,
,
,
,
,
,
IEEE Trans. Biomed. Eng., 2018
Identification of Ultrasonic Echolucent Carotid Plaques Using Discrete Fréchet Distance Between Bimodal Gamma Distributions.
IEEE Trans. Biomed. Eng., 2018
DIMENSION: Dynamic MR Imaging with Both K-space and Spatial Prior Knowledge Obtained via Multi-Supervised Network Training.
CoRR, 2018
Classifying Mammographic Breast Density by Residual Learning.
CoRR, 2018
Local and Non-local Deep Feature Fusion for Malignancy Characterization of Hepatocellular Carcinoma.
Proceedings of the Medical Image Computing and Computer Assisted Intervention - MICCAI 2018, 2018
2017
Development of a Mechanical Scanning Device With High-Frequency Ultrasound Transducer for Ultrasonic Capsule Endoscopy.
,
,
,
,
,
,
,
,
,
,
,
,
,
IEEE Trans. Medical Imaging, 2017
Modulated Excitation Imaging System for Intravascular Ultrasound.
IEEE Trans. Biomed. Eng., 2017
Malignancy characterization of hepatocellular carcinoma using hybrid texture and deep features.
Proceedings of the 2017 IEEE International Conference on Image Processing, 2017
2016
Theoretical and Experimental Investigation of Ultrasonic Transducers With Dual Oppositely Polarized PMN-PT Layers in Wide Frequency Range.
IEEE Trans. Ind. Electron., 2016
Effects of Non-Elevation-Focalized Linear Array Transducer on Ultrasound Plane-Wave Imaging.
Sensors, 2016
2015
An easily-achieved time-domain beamformer for ultrafast ultrasound imaging based on compressive sensing.
Proceedings of the 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2015
A new shear wave imaging system for ultrasound elastography.
Proceedings of the 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2015
Controlled thermal-sensitive liposomes release on a disposable microfluidic device.
Proceedings of the 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2015
2014
Pulsatile Flow Characterization in a Vessel Phantom With Elastic Wall Using Ultrasonic Particle Image Velocimetry Technique: The Impact of Vessel Stiffness on Flow Dynamics.
IEEE Trans. Biomed. Eng., 2014
A Digital Multigate Doppler Method for High Frequency Ultrasound.
,
,
,
,
,
,
,
,
,
,
,
Sensors, 2014
Comparative study on shear wave speed estimation algorithms in ARFI for improving its reliability.
Proceedings of the 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2014
Scanning-mode 2D acoustic radiation force impulse (s2D-ARFI) imaging based on GPU acceleration.
Proceedings of the 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2014
Teeth segmentation using dental CT data.
Proceedings of the 7th International Conference on Biomedical Engineering and Informatics, 2014
2013
A Novel Modulated Excitation Imaging System for Microultrasound.
IEEE Trans. Biomed. Eng., 2013
Quantitative analysis of peri-tumor tissue elasticity based on shear-wave elastography for breast tumor classification.
Proceedings of the 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2013
Open system for micro-ultrasound.
Proceedings of the 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2013
Ultrasound contrast image segmentation using a modified level set method.
Proceedings of the 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2013
2011
Geometric Calibration of a Micro-CT System and Performance for Insect Imaging.
IEEE Trans. Inf. Technol. Biomed., 2011
Non-invasive assessment for endothelial CD81 expression via targeted microbubbles.
Proceedings of the 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2011
Two-dimensional flow study in a stenotic artery phantom using ultrasonic particle image velocimetry.
Proceedings of the 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2011
A simulation study of dynamic MRI based on partially separable functions and keyhole techniques.
Proceedings of the 4th International Conference on Biomedical Engineering and Informatics, 2011
Multi-component hemodynamic measurement in flexible vascular phantom using echo particle image velocimetry.
Proceedings of the 4th International Conference on Biomedical Engineering and Informatics, 2011
Performance evaluation of a prototype pneumatic driver for MR elastography by MR elastography.
Proceedings of the 4th International Conference on Biomedical Engineering and Informatics, 2011
2010
Real-Time Visualized Freehand 3D Ultrasound Reconstruction Based on GPU.
IEEE Trans. Inf. Technol. Biomed., 2010
Real-Time Visualization and Interaction of Three-dimensional Human CT Images.
J. Comput., 2010
2009
A Novel Interactive Image Processing Approach for DICOM Medical Image Data.
Proceedings of the 2nd International Conference on BioMedical Engineering and Informatics, 2009
2004
Advantages in Using Multi-Frequency Driving to Enhance Ultrasound Contrast Microbubble Non-Linearities for Optimizing Echo Particle Image Velocimetry Techniques.
Proceedings of the 2004 IEEE International Symposium on Biomedical Imaging: From Nano to Macro, 2004